Prior to medical transition, I depended on anti-depressants and anti-anxiety medications that I phased out afterwards with no trouble. My sense of smell seems way more sensitive than before, and I had some minor hot flashes a few months into HRT. In order to have surgery recently, I was asked to reduce my HRT for a month, which certainly affected my mood and tested my BFF's patience! It seems like my brain was hard-wired for this stuff, or could that just be me feeling happier?