I has happened to me. My wife left me because of the crossdressing. We had been married quite some time. She just left while I was at work. Now that she is gone, I have an emptiness in my sole that can not be refilled. The depression is so great that I can't find anything to snap it out of me.
The hardest part is unwinding years of marriage by myself. She left and went to another state. It is up to me to pack all the things up and get it ready for her move. Going thru the memories of our life together without her here is shear torture. There were many happy times that are captured in trinkets and pictures.
Separating those out is difficult to say the least.
Maybe the pain will abate once I get her things packed and out of the house. Maybe the pain will stop once I decide to get on with my life. It is hard to come to grips with all this.