I have taken antidepressants off and on over the years. I had the same experience with Celexa and other antidepressants - they reduced my desire to crossdress. The most recent time I was taking Celexa (a couple of months ago) they almost completely killed my libido and my ability to orgasm so I quit taking them. Now I am taking St. John's Wort, which not only seems to help the depression, it doesn't kill my libido (at least not as much) nor does it kill my ability to orgasm so I would definitely recommend it.