I'll channel Kaitlyn here for a moment and say that I don't have enough data points to find the line between GD-related depression and depression that is congenital. I'm still aware that I cycle, for example, but it has become so mild that I don't really notice it much. The fact that the cycling is there tells me the congenital bipolar syndrome is still in play. But the associated highs and lows have had a ceiling and floor installed, so to speak. Is the the ADs or hormones or both? I can't tell at this point (18 months on ADs, a year on hormones). The only way I might is to stop one, the other, or both. Hormones? ... Not happening! AD's? I've thought about it from time-to-time. My therapist became alarmed when I bought it up. Probably not a good idea ...