I guess one's answer depends on quite a number of variables. I haven't thought about this one for quite some time. It really got me thinking.
If I had only one wish it would be to spend all time and eternity with those who I love both currently living and those who have passed away.
If it was only one wish regarding my time here on earth it would be that my wife and I happily live to old age together, and are successful enough along he way to be comfortable in retirement and have some travel money.
If it was one wish regarding a personal relationship I value, I would wish that my sister and I could communicate more easily.
If it were a wish related to my CD'ing I am not sure which of the following I would choose.
1. My wife's acceptance
2. My self acceptance
3. Wishing CD'ing away
4. Having a real friend that understands or is accepting (The only person I have ever told is my wife)
I feel all four would make things easier, and some times any of them would suffice. I am working on #2 but not all the way there yet.