I would not have approached them and said anything, at most I might have made eye contact.

I worked in a convince store for awhile and there was a person that would come in sometimes as a man and sometimes as a woman. At first I thought that they were a crossdresser like myself, but I didn't want to make him/her feel uncomfortable. I treated this person the same no matter how they came in dressed. I found out later that he was a MtF from a co-worker that knew him and his ex-wife.