Re: arrhythmia - A LOT of things can cause this, as you know, including cholesterol issues, which you specifically mentioned. Estrogen in hormone replacement regimens can affect one part of the heart’s electrical cycle, but as far as I know hasn’t been looked at specifically in TS.

Spiro is well-known for causing potassium problems (I’m affected) and sodium/potassium imbalances can also cause arrythymias and even arrest. You obviously don’t take Spiro, though.