When it comes to women and to what degree (if any) they are accepting of crossdressers and transgender individuals in general, I think that much of it comes down to plain NIMBYism ("Not In My Back Yard"). They might enjoy watching RuPaul's Drag Race, religiously follow the many YouTube videos featuring male makeup artists glamming it up, or hanging on every word of advice from gay fashion gurus, but when it hits closer to home and involves seeing a husband, boyfriend, or even a brother donning a dress and acting "girly", in many cases the "Ewww!" factor kicks in pretty quickly.
As for teenage girls, yes, they are a complicated bunch, and they are often conflicted by their budding sexuality until they have that part of their lives all sorted out. How else to explain their being "boy crazy" once the hormones from puberty start to flow, being fascinated by "bad boys", and yet at the same time being such rabid fans of the ubiquitous "boy bands", Justin Bieber, Shawn Mendes and the like who project a neutered, "safe" and unthreatening version of masculinity that they can still feel comfortable around?
My guess is that they have similar, largely un-informed (and unformed) views of crossdressers and transgender people, and would likely react to them in a far more neutral and accepting fashion if they encountered such an individual one-on-one. Of course, when the pack mentality of a group of teenage girls overrides those individual, more benign instincts, then it becomes a whole different ballgame as some others here have already pointed out.