Hi Patty! I have used estradiol patches for about 20 months and have never had one fall off. Assuming you're placing them on clean, hairless skin, do you do a lot of athletic activity? Vigorous moving and perspiration can effect their adhesion. If this is the case, than what you are doing is OK, add a band-aid or some medical tape. There is a remote possibility that the batch of patches you are using is defective and therefore a problem with the glue. I hope this helps.
