I challenge the beliefs that underlie these statements. Do they believe that gender and sexual variance, or for that matter, race and religions that are different than their own are inferior? Sick? An aberration? A bad choice that people make?

Usually comments like this are made from ignorance and all it takes is some education, unless the values are based in religious beliefs. It is difficult to change faith based values.

But if reasoning fails, I simply say that I am offended by remarks that put down an entire group of people who had no say in the way they were born, or their upbringing if they were raised in a culture different than ours.