David Duchovny, best known as Fox Muldar on the X-Files, may be a crossdresser in real life. There are two photos of him that floated around the web. One is just a face shot of him wearing full fashion makeup. The other is of him and Gillian Anderson. She is wearing a suit and he is wearing a bridesmaid type gown and she is holding him in her arms.
Before the X-Files, he had a brief appearance in Twin Peaks. He appeared in 2 or 3 episodes as a crossdressed FBI agent. He comes to Twin Peaks to help Agent Cooper, and works exclusively as a woman.