Trans people are born with it... as opposed to what, exactly? Who would choose to be a transsexual? Certainly not transsexuals, who would rather be born right in the first place. Who would give up family, friends, job, house and all their Playstation games for any reason other than they HAD to? That having been said, I used to think it was genetic, but I know identical twins, one who is a transman, one who is not. If their genes were the same then they both should be trans. I think what happened was that they got a different dose of hormones in the womb. Either way, being trans in NOT a choice.
But yeah I agree with Valenstein, that Johns Hopkins case she mentioned was very highly publicized, and was a huge example that internal gender isn't a social construct, and therefore not changeable. Though to be fair there are quite a few people who might think they are transgendered, but arent.