I've heard it used by some to dismiss people with gender issues as just being perverts. It's often derogatory, but then so are most other words used to refer to people with gender issues. But I'd say that autogynephilia is more derogatory than most terms to me. Although I know plenty fetishistic crossdressers who are nice people, I don't like people assuming that I'm some horny dude who gets turned on by dressing like a woman when I'm pretty much the opposite of that.

But the term autogynephilia applied to transwomen is absurd. What's the alternative -- being turned on by your male qualities? Of course I'm more excited about being a woman.