All the relationships you annotated are really secondary to the relationship you have with your wife. Yes, you can get a new job. You can dump old friends for new ones. Even your children and parents may accept the change. How about the woman you are married to? What's her take on taking hormones and/or transitioning? Are you willing to trade her in for another, if she is not accepting of this change or even body modification?
You need to ask for her input. She may not go along for the ride.
