I WAS on a low dosage regimen for quite a while. My Spiro dosage was about a fifth of what most people take for well over a year. It is still only about half of what many people take. I started Spiro a month or two before estradiol. THAT (E) dosage was the minimum available for about six months and then still low after that for that first year and a half. None of this was out of a desire to be on a low dose regimen but was due primarily to potassium problems. As a result, for a long time my T was a lot higher than it should have been. Fortunately, the last increase in estradiol finally managed to wrestle that down to normal female levels in conjunction with the Spiro
Contrary to Stacy's comments above, there were noticeable changes in the first year. So you never know.
