I know people that say spiro killed any male response. For me I took high doses for a couple of years and was still able to function as a male. Just less size and very limited output. (GRS has fixed all of that)
This guide talks about some of what you are asking...
http://www.vch.ca/transhealth/resour...rmones-MTF.pdf Page 9 talks to some of your questions.
Terri
